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Structuring Time in Human Lateral Entorhinal Cortex

Remembering event sequences is central to episodic memory and thought to be supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a fixed …

Deforming the metric of cognitive maps distorts memory

Environmental boundaries anchor cognitive maps that support memory. However, trapezoidal boundary geometry distorts the regular firing patterns of entorhinal grid cells proposedly providing a metric for cognitive maps. Here, we test the impact of …

Distorting the metric of spatial memory

Entorhinal grid cells are characterized by spatially periodic patterns of activity and have been suggested to provide a metric of space. However, environmental geometry distorts grid-cell firing patterns in highly polarized trapezoidal compared to …

Hexadirectional coding of visual space in human entorhinal cortex

Entorhinal grid cells map the local environment, but their involvement beyond spatial navigation remains elusive. We examined human functional MRI responses during a highly controlled visual tracking task and show that entorhinal cortex exhibited a …

An event map of memory space in the hippocampus

The hippocampus has long been implicated in both episodic and spatial memory, however these mnemonic functions have been traditionally investigated in separate research strands. Theoretical accounts and rodent data suggest a common mechanism for …

Grid-cell representations in mental simulation

Anticipating the future is a key motif of the brain, possibly supported by mental simulation of upcoming events. Rodent single-cell recordings suggest the ability of spatially tuned cells to represent subsequent locations. Grid-like representations …